Sociodemographic and Neuroimaging Evaluation of Patients with Multiple Sclerosis and Radiologically Isolated Syndrome in Isfahan, Iran

Background: Multiple sclerosis (MS) is categorized into four subtypes, including clinically-isolated syndrome (CIS), primary progressive multiple (PPMS), secondary (SPMS), and relapsing-remitting (RRMS). On the other hand, radiologically-isolated (RIS) characterized by imaging manifestations of MS rather than its clinical symptoms. Objectives: This study aimed to compare sociodemographic neuroimaging findings different phenotypes RIS. Methods: The current cross-sectional was conducted on 3716 patients at Sclerosis Clinic Kashani Hospital, Isfahan, Iran, from June 2018 April 2019. Patients presenting with RIS, CIS, were included in this study. Results: age disease onset remarkably lower RRMS, while body mass index significantly higher RIS (P-value < 0.05). Other factors, gender, occupation, marital status, smoking, family history MS, showed no significant difference > Neuroimaging assessments revealed differences terms location plaques, activity brain atrophy, lesion load, number cervical presence longitudinally-extended transverse myelitis 0.05), but not regarding thoracolumbar plaques lesions Conclusions: Different variations characteristics. Follow-up studies are recommended determine risk factors predicting conversion CIS phenotypes.